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Nanocatalytic medical materials and applications

Chemokinetic treatment of tumors using nanocatalysts. Chemokinetic therapy is a treatment that uses nanocatalysts to initiate in situ catalytic reactions in the tumor microenvironment, produce reactive oxygen species or other toxic substances, causing oxidative damage or toxic killing to tumor cells. This method has the advantages of high efficiency, specificity and low toxicity, which can overcome the limitations of conventional chemotherapy. Based on Fenton catalytic reaction synergy old medicine new tumor treatment strategy, using mesoporous silica nanoparticles will disulfiram and copper ions to the tumor site, released in tumor acid environment, double sulfiram and copper ion chelation enhanced toxicity and copper ion catalytic hydrogen peroxide hydroxyl radical synergistic effect, thus effectively inhibit tumor growth. Photodynamic treatment of tumors using nanocatalysts. Photodynamic therapy is a therapeutic approach that uses photosensitizers to generate singlet oxygen or other reactive oxygen species for phototoxic killing of tumor cells. This method has the advantages of high selectivity, low invasive nature and low drug resistance, but is also limited by the anaerobic features of tumors and the depth of light penetration. Based on the strategy of photosynthesis-enhanced photodynamic therapy, hybrid photosensitive bacteria with dihydroporphyrin are used to achieve photosynthetic and photosensitizer activation under excitation of a single light source, thus improving the oxygen content and singlet oxygen production in tumors, thus effectively inhibiting tumor growth.

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