Preparation of manganese-doped calcium phosphate and photothermal / chemokinetic therapy
The preparation of manganese-doped calcium phosphate and the study of photothermal / chemokinetic therapy guided by nuclear magnetic imaging are a new technique for tumors using manganese-doped calcium phosphate nanoparticles. Manganese doped calcium phosphate nanoparticles is a kind of high biocompatibility, low toxicity, high stability and tunability of nanomaterials, can through different synthesis methods and surface modification strategy, achieve targeted delivery and responsive release of tumor, and with other treatments such as magnetic imaging, photothermal therapy, chemodynamic therapy combined therapy, improve the efficiency and safety of tumor treatment. Manganese-doped calcium phosphate nanoparticles can be degraded in the acidic tumor microenvironment, thus releasing payloads such as manganese ions, drugs, and enzymes. Manganese ion can be used as nuclear magnetic contrast agent to realize visual monitoring of tumor; drugs can kill tumor cells directly through chemical therapy; enzymes can catalyze the oxidation of glucose to produce hydrogen peroxide and gluconic acid, thus inducing starvation and hypoxia of tumor cells; hydrogen peroxide can produce highly active hydroxyl-like reaction, thus realizing chemodynamic therapy; hydroxyl radical can enhance the effect of photothermal therapy and inactivate tumor cells by producing local high temperature. Through such a cascade reaction, manganese-doped calcium phosphate nanoparticles can achieve nuclear magnetic imaging-guided photothermal / chemo-dynamic synergistic therapy, with high efficiency, low toxicity and multiple function, and it is a promising medical technology.
A multifunctional drug carrier system based on manganese-doped perovskite-type perovskite (MnCAP) nanoparticles for photothermal / chemo-dynamic MRI-guided synergistic therapy. The system uses MnCAP nanoparticles as a carrier, loading Doxorubicin (DOX) as an anticancer drug and glucose oxidase (GOx) as a catalyst, and improves its stability and biocompatibility through polyethylene glycol (PEG) modification. This system enables effective killing of tumor cells in in vitro and in vivo models and monitors its in vivo distribution and degradation by nuclear magnetic imaging.
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