small: NIR activated multi-modal photothermal/chemical/kinetic doped Fe(II) ion (Fe-Ti3C2) imaging nano-platform for anticancer agent
one.Article overview
2DMXene, Ti3C2 (TC), due to its biocompatibility and excellent photothermal conversion ability, has shown great application potential in photothermal therapy (PTT). However, due to the basic shortcomings of monotherapy and the complex tumor microenvironment (TME), some tumor ablation is difficult to achieve completely through monotherapy. In this article, the author immobilized appropriately doped Fe2+ ions in a two-dimensional ultra-thin TC nanosheet, and synthesized a new type of Fe(II)-Ti3C2(FTC) multifunctional through electrostatic adsorption between the layers. Nanoshells.
The Fenton reaction based on ferrous ions gives FTC near-infrared (NIR) laser-triggered release and glutathione (GSH) inhibition, and has good biocompatibility and curative effect on hypoxic TME. At the same time, magnetic resonance imaging (MRI) has revealed its potential as a comprehensive diagnostic and therapeutic nano-platform.
Two, graphic guide
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