Nano-CRISPR支架（Nano-CD）
| 【Numbering】BKMC128004 | 【CAS】CAS | ||
| 【Item No.】BKMC128004-2 | 【specification】 | ||
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名稱：Nano-CRISPR支架（Nano-CD）
組成：氨基酸修飾的PEI + CRISPR/dCas9質(zhì)粒+ 順鉑+ TAT+ 聚乙二醇化聚丙烯酸(PAA)骨架
粒徑：100-200nm
應(yīng)用：離子視覺傳感
儲(chǔ)存條件：-4℃
其他說(shuō)明：密封狀態(tài)下保質(zhì)期半年【主要優(yōu)勢(shì)】Nano-CD利用從功能篩選中選擇的特定sgRNA觸發(fā)內(nèi)源性GDSME表達(dá)，同時(shí)釋放順鉑啟動(dòng)免疫細(xì)胞死亡。此外其可以聯(lián)合檢查點(diǎn)阻斷可產(chǎn)生持久的免疫記憶和強(qiáng)大的全身抗腫瘤免疫反應(yīng)，從而預(yù)防疾病復(fù)發(fā)，抑制肺轉(zhuǎn)移，提高小鼠黑色素瘤的生存率。
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組成：氨基酸修飾的PEI + CRISPR/dCas9質(zhì)粒+ 順鉑+ TAT+ 聚乙二醇化聚丙烯酸(PAA)骨架
粒徑：100-200nm
應(yīng)用：離子視覺傳感
儲(chǔ)存條件：-4℃
其他說(shuō)明：密封狀態(tài)下保質(zhì)期半年【主要優(yōu)勢(shì)】Nano-CD利用從功能篩選中選擇的特定sgRNA觸發(fā)內(nèi)源性GDSME表達(dá)，同時(shí)釋放順鉑啟動(dòng)免疫細(xì)胞死亡。此外其可以聯(lián)合檢查點(diǎn)阻斷可產(chǎn)生持久的免疫記憶和強(qiáng)大的全身抗腫瘤免疫反應(yīng)，從而預(yù)防疾病復(fù)發(fā)，抑制肺轉(zhuǎn)移，提高小鼠黑色素瘤的生存率。
Title:A cooperative nano-CRISPR scaffold potentiates immunotherapy via activation of tumour-intrinsic pyroptosis
Article link:https://www.163.com/dy/article/HTFL7SKO0534TMVS.html
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